The interactions that determine the solubility of a substance in a liquid depend largely on the chemical nature of the solute (such as whether it is ionic or molecular) rather than on its physical state (solid, liquid, or gas). Jae‐Woo Park. However, MeCN shows irregular behavior suggesting the presence of interactions between the ester and MeCN. Amphiphilic molecules, such as humic substances and surfactants, are known to increase the apparent aqueous solubility of hydrophobic organic compounds (HOCs) in the aqueous phase because of their molecular structures, which consist of hydrophilic and hydrophobic moieties. Molecular symmetry has a pronounced effect on the melting properties and solubility of organic compounds. Non-polar liquids, like C6H6 (benzene) and CCl4, dissolve readily in other non-polar liquids, but not very readily in polar liquids. Polar liquids, like HO-CH2-CH2-OH (ethylene glycol) and H2O, dissolve readily in other polar liquids, but not very readily in non-polar liquids. Effect of molecular structures on the solubility enhancement of hydrophobic organic compounds by environmental amphiphiles. Symmetry in a m Hyun‐Hee Cho. Why is this the case? Corresponding Author. dues such as proline and leucine in the molecular structure of wheat gluten protein and nondissociable polar glutamine residues, gluten protein mainly exists in large aggregates under neutral conditions. From solubility measurements in MeOH, EtOH, MeCN, and c-hexane (c-Hxn), it was found that each ester has the lowest solubility in MeOH and the highest solubility in c-Hxn. National Subsurface Environmental Research Laboratory, Ewha Womans University, 11–1 Daehyon‐dong, Seodaemun‐gu, Seoul, 120–750, Korea . These results indicate that the decrease of polarity of the solvents make the solubility increase. Search for more papers by this author. As a general rule, symmetrical molecules in crystalline form have higher melting temperatures and exhibit lower solubilities compared with molecules of similar structure but with lower symmetry. Effect of Molecular Structure on Solubility. Read "Effect of molecular structures on the solubility enhancement of hydrophobic organic compounds by environmental amphiphiles, Environmental Toxicology & Chemistry" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. We investigate systematically the effect of surfactant molecular structure on Progesterone solubility by using a set of 17 surfactants with different hydrophilic head group charge and variable hydrophobic chain length.