Other systemic examinations revealed no abnormalities. He continued to be anuric, hence, hemodialysis was started via his left femoral vein. Three cases are reported which presented to our Emergency Department. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Çadirci K, Özdemir Tozlu Ö, Türkez H, Mardinoğlu A. Turk J Med Sci. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The body burden of formate in methanol poisoning is high enough to cause acidosis, and other clinical symptoms. 2020 Jul 18;41(4):444-448. doi: 10.24272/j.issn.2095-8137.2020.088. Folinic acid hastens FA degradation, hence it was given as an additional treatment . 2020 Mar 16;17(6):1940. doi: 10.3390/ijerph17061940. Lend a hand to your fellow Cureus authors and volunteer for our peer review panel. It was determined he had sepsis with disseminated intravascular coagulation (DIC). On day three, his serum urea was 134 mg/dL and serum creatinine was 4.8, serum potassium level was 5.1 mmol/dl and his total leucocyte count was 13,600 cells/cm3. His internal jugular vein (IJV) hemodialysis catheter was changed and reports turned out to be negative. case of unknown poisoning. (May 06, 2020) An Atypical Presentation of Formic Acid Poisoning. A 73-year-old man with an alleged history of poison consumption was brought to the hospital. dilatation of cerebral vessels, facilitation of the entry of calcium ions into cells, loss of lysosomal latency and deranged production of ATP. Vyata V, Durugu, Jitta S, et al. Despite starting on diuretics initially, the patient was worsening from oliguria to anuria. Initial symptoms are appeared within 12-24 hr and after it second set of symptom arises. formic acid, poisoning, : acute kidney injury, Vishruth Vyata , Satya Durugu, Sahas Reddy Jitta, Shriya Khurana, Jaswanth Rao Jasti, Cite this article as: NIH Formic acid is directly toxic to the retina, and may lead to blindness. "Never doubt that a small group of thoughtful, committed citizens can change the world. Many of these workers often consume FA accidentally or with suicidal intentions. 1980 Mar;68(3):414-8. doi: 10.1016/0002-9343(80)90113-8. Hemodialysis was later performed via his right internal jugular vein. Most importantly, the antidepressant dosage was optimized to prevent another suicide attempt or suicidal ideations. © Copyright 2020Vyata et al. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. The formic acid then leaves the body in urine or is changed into carbon dioxide and water. The formic acid then leaves the body in urine or is changed into carbon dioxide and water. Meticulous supportive treatment was the main contributor to successful treatment. 2002;40(4):415-46. doi: 10.1081/clt-120006745. They were also advised to keep any potentially harmful substances away from him given his history of depression. HHS Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. This sequence of events may partially explain an accumulation of formate in urine. However, this patient, despite consuming 15-20 ml of FA and alcohol, was successfully treated. (May 06, 2020) An Atypical Presentation of Formic Acid Poisoning. The patient had a slow recovery from his acute kidney injury. Oral ingestion of 10 ml FA is usually fatal and 15 ml usually causes death before even reaching the hospital . 2 Nearly 90% of cases of formic acid poisoning are with intention of suicide and only 10% are accidental consumption.2 It is observed that most of the victims mix formic acid with alcohol while He was advised for regular follow-ups. Please note that Cureus is not responsible for any content or activities contained within our partner or affiliate websites. Besides, urinary acidification is affected by formic acid. The patient’s arterial blood gas analysis revealed a pH of 7.26, bicarbonate (HCO3) concentration of 14.0 mmol/L, and partial pressure of carbon dioxide (pCO2) level 32.3 mmHg. Acute kidney injury was anticipated at the start as the patient had dark cola-colored urine on admission despite normal renal function test. It is important to repeat the renal function test despite a normal report in order to best anticipate acute kidney injury. Many FA poisoning cases commonly involve rubber plantation workers in which these workers ingest FA accidentally or with suicidal intentions. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. However, the patient developed urinary retention. USA.gov. The body burden of formate in methanol poisoning is high enough to cause acidosis, and other clinical symptoms. The man’s renal function test revealed serum urea of 28 mg/dL and creatinine of 1.4 mg/dL.