The cook time for baked salmon does not vary much between 350 and 375. To bake salmon, first preheat your oven to 450°F (230°C) and line a baking sheet with aluminum foil. How long do you bake salmon in the oven at 400? At 400 degrees, salmon will bake in about 10 – 12 minutes. In general, a large (2-pound) side of salmon bakes at 375 degrees F in 15 to 20 minutes. Keep an eye on the salmon because it can overcook quickly at the higher temperatures. Then, place the salmon skin-side down on the sheet. Directions - 6 When it reaches approximately 125 degrees Fahrenheit, broil the fish some more for … How Long to Bake Salmon in Foil. Add salmon skin-side down and let cook 6 to 8 minutes, or until the bottom half of the fish looks opaque and the skin easily releases from the grill. Bake the fish at 375 degrees Fahrenheit and let it cook for about 10 to 13 minutes. Brush the top and sides of the salmon with olive oil, then season with salt and pepper. The cooking time can be several minutes longer or shorter depending upon the thickness of your particular piece of salmon. This is the size of the salmon you see in these photos. Bake the salmon for 4 to 6 minutes per ½ inch (1 ½ cm) of thickness.