Death, coma, and encephalopathy have been reported as sequelae of these events. 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The man immediately collapses. Patients with mild to moderate hypertension who receive Naloxone during labor should be carefully monitored as severe hypertension may occur. In a neonatal study the mean plasma half-life was observed to be 3.1 ± 0.5 hours. Intramuscular or subcutaneous administration may be necessary if the intravenous route is not available. Naloxone hydrochloride injection USP, for intravenous, intramuscular, and subcutaneous administration is available as: Each carton contains one 2 mg/2 mL Single-Dose Luer-Lock Prefilled Syringe and a 21 G x 1 ½” safety needle. Generic Name: Naloxone hydrochloride An initial dose of 0.4 mg to 2 mg of Naloxone hydrochloride may be administered intravenously. One study of two neonates in septic shock reported a positive pressor response; however, one patient subsequently died after intractable seizures. Caution should be exercised when Naloxone hydrochloride is administered to this patient population. Pentazocine is a mixed agonist-antagonist at opioid receptors. Reversal of respiratory depression by partial agonists or mixed agonist/antagonists, such as buprenorphine and pentazocine, may be incomplete or require higher doses of Naloxone. Naloxone is a drug specifically designed to treat overdose of opiates, or compounds derived from opiate plants, such as heroin. Naloxone hydrochloride injection is contraindicated in patients known to be hypersensitive to Naloxone hydrochloride or to any of the other ingredients in Naloxone hydrochloride. However, some patients may slip back into unconsciousness and need additional doses of naloxone until they can be treated fully at a hospital. imaginable degree, area of If an intravenous route of administration is not available, Naloxone may be administered intramuscular or subcutaneous in divided doses. Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature]. Endorphins do this by binding to opiate receptors on cells of our nervous system, or neurons, in the brain and spinal cord. Abrupt postoperative reversal of opioid depression may result in nausea, vomiting, sweating, tremulousness, tachycardia, increased blood pressure, seizures, ventricular tachycardia and fibrillation, pulmonary edema, and cardiac arrest which may result in death. Pediatric reports include a 2-1/2 year-old child who inadvertently received a dose of 20 mg of Naloxone for treatment of respiratory depression following overdose with diphenoxylate hydrochloride with atropine sulfate. Gently tap the syringe to remove any visible bubbles and expel air from the syringe prior to administration. It is commonly used to counter decreased breathing in opioid overdose. By binding to the opioid receptors, naloxone displaces both opioid agonists and partial antagonists, such as pentazocine. Their breathing slows, and they can experience brain damage from loss of oxygen and quickly die. Excessive doses of Naloxone hydrochloride in postoperative patients may result in significant reversal of analgesia and may cause agitation (see PRECAUTIONS and DOSAGE AND ADMINISTRATION; Usage in Adults-Postoperative Opioid Depression). Although a direct cause and effect relationship has not been established, Naloxone hydrochloride should be used with caution in patients with pre-existing cardiac disease or patients who have received medications with potential adverse cardiovascular effects, such as hypotension, ventricular tachycardia or fibrillation, and pulmonary edema. Respiratory, Thoracic and Mediastinal Disorders:dyspnea, respiratory depression, hypoxia Did you know… We have over 220 college It is not known if Naloxone hydrochloride injection, USP affects the duration of labor and/or delivery. Attach and screw the syringe to the needle using aseptic technique. In people with opioids in their system, it may cause increased sweating, nausea, restlessness, trembling, vomiting, flushing, and headache, and has in rare cases been associated with heart rhythm changes, seizures, and pulmonary edema. What are the different types of buprenorphine/naloxone? His breathing slowed, and she barely got him to the hospital. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The severity and duration of the withdrawal syndrome are related to the dose of Naloxone hydrochloride and to the degree and type of opioid dependence. Each mL also contains 9 mg of sodium chloride. courses that prepare you to earn All other trademarks and copyrights are the property of their respective owners. Observe patient closely; duration of action of some narcotics may exceed that of naloxone. Teratology studies conducted in mice and rats at doses 4-times and 8-times, respectively, the dose of a 50 kg human given 10 mg/day (when based on surface area or mg/m2), demonstrated no embryotoxic or teratogenic effects due to Naloxone hydrochloride. Create your account, Already registered? Dispose used needles and materials following the policies and procedures of your facility as well as federal and local regulations for sharps disposal.